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Science (2011) 334(6057):8259

This could be partly explained by the limited protection of Nrf2 against disease markers in backcross experiments between ALS mice and Nrf2-null mice, presumably as a result of compensatory mechanisms (Vargas et al

30,31,32,33 Raptor-deficient T cells also exhibit defects in de novo lipid synthesis and oxidative phosphorylation, suggesting the mTOR pathway is a global regulator of T cell metabolic programs